Senior HR Business Partner

About the role

Orchard Therapeutics, a global biotechnology gene‑therapy company, is seeking a Senior HR Business Partner to act as a strategic partner to C‑level functional leaders. Based in London, the role will support the development and delivery of people strategies that drive organisational performance, capability and culture across a global, matrixed environment.

Key responsibilities

• Partner with senior, C‑level executive leadership and global functional leaders to provide strategic HR guidance across the employee lifecycle.
• Build trusted relationships and coach leaders to enhance capability, leadership effectiveness and organisational performance.
• Act as a strategic partner in hiring, collaborating with Talent Acquisition to define workforce needs and ensure high‑quality, timely hiring outcomes.
• Drive annual talent management processes, including goal setting, talent and succession reviews, performance management and compensation planning.
• Develop and implement business‑aligned HR strategies that support organisational goals, growth and transformation.
• Contribute to the development of the HR function by coaching team members and supporting the Head of HR.
• Ensure effective utilisation and continuous improvement of HR systems, promoting data accuracy and insight‑driven decision making.
• Lead employee‑relations matters, ensuring appropriate handling, resolution and risk mitigation.
• Monitor external trends and best practices to inform HR strategy and continuous improvement.
• Ensure compliance with applicable employment legislation, policies and procedures.

Required profile

• Significant global HR generalist experience, ideally within a complex, matrixed, international organisation.
• Proven track record as an HR Business Partner influencing senior leaders to enhance organisational performance and drive change.
• Strong business acumen with the ability to influence executive and functional leadership on people‑related matters.
• Strong working knowledge of HR practices and employment frameworks across multiple geographies.
• Demonstrated ability to build credible, trusted relationships and operate effectively at all organisational levels.
• Skilled in coaching and influencing leaders.

Required skills