Pharmacometrics Support Programmer

About the role

ICON is looking for an experienced Pharmacometrics Support Programmer to join a global FSP team in Reading. The role suits a highly analytical programmer with strong R programming expertise and PK/PD data preparation experience, who will create, quality control and standardise NONMEM PK/PD datasets for drug development programmes. You will work closely with Data Management, Statistical Programming, Statistics, Bioanalytical teams and external partners.

Key responsibilities

• Develop and quality control NONMEM PK/PD datasets using SDTM and ADaM data sources.
• Support pharmacometric modelling by delivering accurate, complete, submission-ready datasets.
• Perform quality review of internally and externally produced NONMEM datasets.
• Collaborate with Data Management, Statistical Programming, Statistics, Clinical Pharmacology and Bioanalytical teams to resolve data issues and meet project timelines.
• Contribute to regulatory submission projects in line with internal pharmacometrics guidelines.
• Run quality control testing of customised R packages and maintain testing frameworks and validation processes for departmental R tools.
• Identify data discrepancies, process improvements and automation opportunities, and help build new pharmacometric standardisation initiatives.
• Ensure deliverables comply with SOPs, working instructions, regulatory requirements and ICH-GCP guidelines, and maintain inspection readiness.

Required profile

• Bachelor's degree in a Life Science, Health Science, Statistics, Computer Science, IT or related discipline.
• At least 6 years of experience in the pharmaceutical, biotechnology or CRO industry.
• Working knowledge of PK/PD principles and pharmacometric workflows.
• Strong attention to detail, excellent written and verbal English, and ability to work across global, cross-functional teams.

Required skills

• Strong R programming expertise.
• Experience developing and quality controlling NONMEM PK/PD datasets.
• Understanding of SDTM, ADaM and CDISC standards, including controlled terminology.
• Experience with NONMEM file creation, quality control, submissions and standardisation.
• Desired: reviewing outsourced programming deliverables, validating customised R packages, and driving standardisation initiatives.

What we offer

• Competitive base salary and performance-related incentives.
• Health and wellbeing programmes, including medical, dental and vision coverage where applicable.
• Retirement and pension plans, life assurance and disability coverage.
• Employee assistance programmes and learning and development opportunities.